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ICFSR 2015: INTERNATIONAL CONFERENCE ON FRAILTY & SARCOPENIA RESEARCH THURSDAY - SATURDAY, APRIL 23-25, 2015 BOSTON, MA, USA
J Frailty Aging 2015;4(S1):19-108Show summaryHide summary
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ICFSR: 8th International Conference on Frailty & Sarcopenia Research, March 1-3, 2018, Miami – USA
Poster, ONLINE EXCLUSIVE
J Frailty Aging 2018;7(S1):92-173Show summaryHide summary
Poster (2018): ICFSR: 8th International Conference on Frailty and Sarcopenia Research, March 1-3, 2018, Miami – USA. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2018.4
THE GREEN TEA POLYPHENOL EPIGALLOCATECHIN-3-GALLATE (EGCG) ATTENUATES SKELETAL MUSCLE ATROPHY IN A RAT MODEL OF SARCOPENIA
B.M. Meador, K.A. Mirza, M. Tian, M.B. Skelding, L.A. Reaves, N.K. Edens, M.J. Tisdale, S.L. Pereira
J Frailty Aging 2015;4(4):209-215Show summaryHide summary
Objective: Sarcopenia—the loss of muscle mass and functionality occurring with age—is a pervasive problem with few effective treatments beyond exercise. We examined the ability of the green tea catechin, epigallocatechin-3-gallate (EGCg), to impact muscle mass and the molecular pathway involved in muscle atrophy in a rat model of sarcopenia. Methods: 20-month-old Sprague-Dawley rats were treated for 8 weeks with control diet or control plus 200mg/kg body weight of EGCg diet. Results: EGCg-supplemented animals had significantly greater gastrocnemius muscle mass than the aged controls, and showed a trend for increased muscle fiber cross-sectional areas (CSA) (p=0.06). These changes were associated with significantly lower protein expressions of the intramuscular 19S and 20S proteasome subunits and the MuRF1 and MAFbx ubiquitin ligases in the EGCg-treated animals. Proteasome activity as determined by ‘Chymotrypsin-like’ enzyme activity was also significantly reduced by EGCg. Muscle mRNA expression of IL-15 and IGF-1 were significantly increased in the EGCg group vs. the aged controls. In comparison to younger adult animals (6 month), the protein expression of 19S, 20S, MuRF1, MAFbx, and myostatin were increased between approximately 4- and 12-fold in the aged controls, but only up to ~2-fold in the aged EGCg animals. Conclusions: EGCg supplementation was able to preserve muscle in sarcopenic rats, partly through attenuating protein degradation via the ubiquitin-proteasome pathway, together with increased expression of anabolic factors.
B.M. Meador ; K.A. Mirza ; M. Tian ; M.B. Skelding ; L.A. Reaves ; N.K. Edens ; M.J. Tisdale ; S.L. Pereira (2015): The green tea polyphenol Epigallocatechin-3-gallate (EGCg) attenuates skeletal muscle atrophy in a rat model of sarcopenia. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2015.58
PREDICTION OF COGNITIVE STATUS AND 5-YEAR SURVIVAL RATE FOR ELDERLY WITH CARDIOVASCULAR DISEASES: A CANADIAN STUDY OF HEALTH AND AGING SECONDARY DATA ANALYSIS
S. Pakzad, P. Bourque, N. Fallah
J Frailty Aging 2021;10(1)31-37Show summaryHide summary
Background: Given the important association between cardiovascular disease and cognitive decline, and their significant implications on frailty status, the contribution of neurocognitive frailty measure helping with the assessment of patient outcomes is dearly needed. Objectives: The present study examines the prognostic value of the Neurocognitive Frailty Index (NFI) in the elderly with cardiovascular disease. Design: Secondary analysis of the Canadian Study of Health and Aging (CSHA) dataset was used for prediction of 5-year cognitive changes. Setting: Community and institutional sample. Participants: Canadians aged 65 and over [Mean age: 80.4 years (SD=6.9; Range of 66-100)]. Measurement: Neurocognitive Frailty Index (NFI) and Modified Mini-Mental State (3MS) scores for cognitive functioning of all subjects at follow-up and mortality rate were measured. Results: The NFI mean score was 9.63 (SD = 6.04) and ranged from 0 to 33. This study demonstrated that the NFI was significantly associated with cognitive changes for subjects with heart disease and this correlation was a stronger predictor than age. Conclusion: The clinical relevance of this study is that our result supports the prognostic utility of the NFI tool in treatment planning for those with modifiable cardiovascular disease risk factors in the development of dementia.
S. Pakzad ; P. Bourque ; N. Fallah (2020): Prediction of Cognitive Status and 5-year Survival rate for Elderly with Cardiovascular Diseases: A Canadian Study of Health and Aging Secondary Data Analysis. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2020.21
ASSOCIATION BETWEEN CONTINUOUS WEARABLE ACTIVITY MONITORING AND SELF-REPORTED FUNCTIONING IN ASSISTED LIVING FACILITY AND NURSING HOME RESIDENTS
J. Merilahti, I. Korhonen
J Frailty Aging 2016;5(4):225-232Show summaryHide summary
Background: Physical functioning is a key factor in independent living, and its preclinical state assessment and monitoring during the subject’s normal life would be beneficial. Objectives: The aim of the study is to analyse associations between ambulatory measured physical activity behaviour and sleep patterns (wrist actigraphy) and self-reported difficulties in performing activities of daily living. Participants, setting and design: 36 residents in assisted living facilities and nursing homes (average age=80.4±9.0 years) without dementia in free living conditions participated. Actigraphic monitoring is integrated with the facilities’ social alarm system. Measurements: Indices on activity level, activity rhythm, sleep pattern and external stimuli response of sleep-wake behaviours were extracted from the actigraph data and correlated (Spearman rank-order correlation) with activities of daily living measures. Bonferroni correction for multiple comparisons was applied. Results: Activity level (ρ=-0.49, p<0.05) and night-time activity variance (ρ=-0.69, p<0.01) had correlation with the activities of daily living scores. The similarity of subject-wise activity pattern to facility common activities had a trend with activities of daily living (ρ=-0.44, p<0.1). In longitudinal case analysis, sleep and activity patterns were found to be associated with local weather variables. Conclusions: Activity patterns as measured by actigraphy may provide objective information on older people’s behaviour related to functioning state and its changes in nursing home and assisted living facility settings. However, variance between individuals was large in this dataset which decreases the reliability of the results. Furthermore, external stimuli such as weather and facility-related activities can affect subjects’ activity and sleep behaviour and should be considered in the related studies as well.
J. Merilahti ; I. Korhonen (2016): Association between continuous wearable activity monitoring and self-reported functioning in assisted living facility and nursing home residents. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2016.102