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02/2013 journal articles

APPENDICULAR LEAN SOFT TISSUE: DEVELOPMENT AND CROSS-VALIDATION OF PREDICTIVE MODELS FOR OLDER MEN AND WOMEN

I.C. Gomes, L.A. Gobbo, A.M. Silva, I.F. Freitas Junior, Y.A.O. Duarte, M.F.N. Marucci, V.R. dos Santos, M.L. Lebrão

J Frailty Aging 2013;2(2):62-67

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Background: Sarcopenia may explain, in a large proportion, physical disability, falls and fractures, especially in aged elderly. However, a diagnosis in an operationally systematic, simple and low cost way is extremely important, particularly for home-based, epidemiological studies. Objective: The purpose of this study was to develop and validate predictive equations of appendicular lean soft tissue (ALST) in elderly older than 80 years. Design and settings: A validation study was performed in 106 elderly (men and women) aged 80 years and older. Measurements: Body weight, height, circumference (arm, midcalf, hip and waist) and triceps skinfold were measured in the elderly. ALST were measured using as the reference method dual-energy X-ray absorptiometry (DXA). Results: Two models were predicted. The first model (ALST, in kg = 0.074*height + 0.277*weight – 0.144*triceps skinfold – 0.103*waist circumference + 1.831*gender -0.966), which considered all possible variables in stepwise multiple regression, presented better statistical performance (r2 = 0.82; SEE = 1.67 kg), compared to the second model (ALST, in kg = 0.138*height + 0.103*weight + 3.061*gender – 12.489), a more practical equation, due to a lesser quantity of predictive variables (r2 = 0.75; SEE = 1.94 kg). Both models were validated, however, it was verified trend (p<0.05) for overestimation of predicted ALST. Conclusion: In summary, two models for predicting ALST in men and women with age ≥ 80 years were developed and cross-validated. Model 1, with a greater number of predictive variables, presented a better accuracy than did the model with only three variables (height, weight, and gender). Validation studies are needed to test the usefulness of both models in other populations.

CITATION:
I.C. Gomes ; L.A. Gobbo ; A.M. Silva ; I.F. Freitas Junior ; Y.A.O. Duarte ; M.F.N. Marucci ; V.R. dos Santos ; M.L. Lebrão (2013): Appendicular lean soft tissue: development and cross-validation of predictive models for older men and women . The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2013.10

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THE COYOACAN COHORT STUDY: DESIGN, METHODOLOGY, AND PARTICIPANTS’ CHARACTERISTICS OF A MEXICAN STUDY ON NUTRITIONAL AND PSYCHOSOCIAL MARKERS OF FRAILTY

L. Ruiz-Arregui, J.A. Ávila-Funes, H. Amieva, S.A. Borges-Yáñez, A. Villa-Romero, S. Aguilar-Navarro, M.U. Pérez-Zepeda, L.M. Gutiérrez-Robledo, R.C. Castrejón-Pérez

J Frailty Aging 2013;2(2):68-76

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Background: “Frailty” has emerged as a condition associated with an increased risk of functional decline among the elderly, which may be differentiated from aging, disability, and co-morbidities. Objective: The Mexican Study of Nutritional and Psychosocial Markers of Frailty among Community-Dwelling Elderly has emerged to help answer many questions about frailty among the older adults. This report presents the design of the study and baseline data of its participants. Design. The “Coyoacan cohort” is a longitudinal observational study developed in Mexico City. Participants: A representative sample of 1,294 non-institutionalized men and women aged 70 years and older were randomly recruited to undergo a face-to-face interview and a comprehensive geriatric assessment (including clinical evaluations and blood samples) between 2008 and 2009. Measurements: Data collected included socio-demographic and economic characteristics, medical history, oral health, drug use, cognitive function and mood, nutritional status, physical performance and functional status, physical activity, quality of life, social networks, and biological data. Frailty was defined as the presence of ≥3 of the following components: slowness, poor muscle strength, low physical activity, exhaustion and unintentional weight loss. Results: A total of 1,124 participants completed the interview. The mean age was 79.5 ± 7.1 years, and 55.9% were female. Nine hundred and forty-five subjects completed the clinical evaluation and 743 blood samples were collected. The baseline prevalence of frailty was 14.1%. Conclusions: Understanding the medical, biological, and environmental factors that contribute to the phenomenon of frailty is the goal of the current research in the field.

CITATION:
L. Ruiz-Arregui ; J.A. Ávila-Funes ; H. Amieva ; S.A. Borges-Yanez ; A. Villa-Romero ; S. Aguilar-Navarro ; M.U. Pérez-Zepeda ; L.M. Gutiérrez-Robledo ; R.C. Castrejon-Pérez (2013): The Coyoacán cohort study: design, methodology, and participants’ characteristics of a Mexican study on nutritional and psychosocial markers of frailty . The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2013.11

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FRAILTY IS ASSOCIATED WITH IMPAIRED QUALITY OF LIFE AND FALLS IN MIDDLE-AGED AND OLDER EUROPEAN MEN

M.D.L. O’Connell, A. Tajar, T.W. O’Neill, S.A. Roberts, D.M. Lee, S.R. Pye, A.J Silman, J.D. Finn, G. Bartfai, S. Boonen, F.F. Casanueva, G. Forti, A. Giwercman, T.S. Han, I.T. Huhtaniemi, K. Kula, M.E.J. Lean, N. Pendleton, M. Punab, D. Vanderschueren, F.C.W. Wu

J Frailty Aging 2013;2(2):77-83

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Objectives: Adapt a measure of frailty for use in a cohort study of European men and explore relationships with age, health related quality of life and falls. Design: Longitudinal cohort study. Setting: 8 European centers. Participants: 3047 men aged 40-79 participating in the European Male Ageing Study (EMAS). Measurements: Frailty was assessed using an adaptation of the Cardiovascular Health Study criteria. Health related quality of life was evaluated using the Rand Short Form-36 (SF-36) questionnaire which comprises both mental and physical component scores. Self reported falls in the preceding 12 months were recorded at 2-year follow-up. Results: 78 men (2.6%) were classified as frail (≥3 criteria) and 821 (26.9%) as prefrail (1-2 criteria). The prevalence of frailty increased from 0.1% in men aged 40-49 up to 6.8% in men aged 70-79. Compared to robust men, both prefrail and frail men had lower health related quality of life. Frailty was more strongly associated with the physical than mental subscales of the SF-36. Frailty was associated with higher risk of falls OR (95% CI) 2.92 (1.52, 5.59). Conclusions: Frailty, assessed by the EMAS criteria, increased in prevalence with age and was related to poorer health related quality of life and higher risk of falls in middle-aged and older European men. These criteria may help to identify a vulnerable subset of older men.

CITATION:
M.D.L. O’Connell ; A. Tajar ; T.W. O’Neill ; S.A. Roberts ; D.M. Lee ; S.R. Pye ; A.J. Silman ; J.D. Finn ; G. Bartfai ; S. Boonen ; F.F. Casanueva ; G. Forti ; A. Giwercman ; T.S. Han ; I.T. Huhtaniemi ; K. Kula ; M.E.J. Lean ; N. Pendleton ; M. Punab ; D. Vanderschueren ; F.C.W. Wu ; and the EMAS group ; (2013): FRAILTY IS ASSOCIATED WITH IMPAIRED QUALITY OF LIFE AND FALLS IN MIDDLE-AGED AND OLDER EUROPEAN MEN . The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2013.12

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EVALUATING RESPONSE MECHANISMS IN A LIFE-SPACE MOBILITY INSTRUMENT WITH A ‘STEM AND LEAF’ FORMAT

C. Siordia

J Frailty Aging 2013;2(2):84-89

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Background: Life-space mobility scales in the very old (aged 80+) have begun to be used as a way of gauging their enacted mobility. Objectives: To investigate if there is evidence that response patterns are being affected by the “stem and leaf” format of a life-space mobility instrument. Methods: Descriptive statistics, readability ease scoring, ten ordinary least square regression on a total of 698 females and 376 males from Wave-7 collected during 2010-2011 for the Hispanic Established Population for the Epidemiological Study of the Elderly. Results: Response patterns seem to indicate that the stem and leaf format of the life-space mobility instrument is not creating item non-response, illogical responses, or ‘no’ responses. Conclusions: Because self-reports are so frequently used, more research is needed to ascertain how instrument formats affect response mechanisms.

CITATION:
C. Siordia (2013): Evaluating Response Mechanisms in a Life-Space Mobility Instrument with a ‘Stem and Leaf’ Format . The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2013.13

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ARE PHYSICIANS HEALTHY WHEN THEY ARE AGED AND RETIRED? A SURVEY OF THE ANKARA CHAMBER OF MEDICINE AND THE TURKISH GERIATRICS SOCIETY

D. Aslan, Y. Gökçe-Kutsal, S. Kanuncu

J Frailty Aging 2013;2(2):90-92

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In literature, there is a lack of knowledge about clinical and lifestyle characteristics of retired physicians. Aim of the study is to describe the health profile of older physicians registered to the Ankara Chamber of Medicine (Ankara, Turkey). Two hundred and seventy four registered physicians agreed to participate to a survery. Most of them (76.6%) were men. Mean age was 74.9 (standard deviation 6.3) years. More than 85% of the participants presented at least one chronic disease. High scores were reported for the role-physical component of the SF-36, differently from the general health section of it scoring low. The results of the present survey pose the basis for collaborative efforts from the Ankara Chamber of Medicine and the Turkish Geriatrics Society collaboratively to improve the design and development of services for local older physicians.

CITATION:
D. Aslan ; Y. Gökçe-Kutsal ; S. Kanuncu (2013): ARE PHYSICIANS HEALTHY WHEN THEY ARE AGED AND RETIRED? A SURVEY OF THE ANKARA CHAMBER OF MEDICINE AND THE TURKISH GERIATRICS SOCIETY . The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2013.14

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1ST INTERNATIONAL SYMPOSIUM OF GRAPA MUSCLE FROM HUMANS TO CELLS, May 3-4, 2013, Montréal, Canada

J Frailty Aging 2013;2(2):93-108

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8TH INTERNATIONAL ACADEMY ON NUTRITION AND AGING (IANA) MEETING, June 23, 2013; Seoul, South Korea

J Frailty Aging 2013;2(2):109-115

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