AGE OF HIV ACQUISITION AFFECTS THE RISK OF MULTI-MORBIDITY AFTER 25 YEARS OF INFECTION EXPOSURE
G. Guaraldi, A. Malagoli, J. Milic, I. Pintassilgo, E. Rossi, N. Riva, I. Franconi, A. Santoro, P. Sorin, A. Streinu-Cercel, M. De Rosa, C. Mussini
J Frailty Aging 2019;8(2):88-92
Introduction: Understanding the intersection of HIV, aging and health is crucial due to the increasing number of people aging with HIV. Objective: The objective of the study was to assess the prevalence of, and risk factors for individual comorbidities and multi-morbidity in people living with HIV with similar duration of HIV infection, notwithstanding a 25-year difference at the time of HIV acquisition. Methods: In a cross-sectional multicentre retrospective study, we compared three match-control age groups. The “Young” were selected from Romania and included HIV-positive patients prenatally infected and assessed at the age of 25-30 years. The “Old” and the “Geriatric” were selected from Italy. These respectively included subjects infected with HIV at the age of 25 years and assessed at the age of 50-55 years, and those infected at the age of 50 years and assessed at the age of 75-80 years. Each group was sex and age matched in a 1:5 ratio with controls selected from the CINECA ARNO database from Italy. We described non-infectious comorbidities (NICM), including cardiovascular disease, hypertension, dyslipidaemia, diabetes, chronic kidney disease, and multi-morbidity (MM≥ 3 NICM). Results: MM prevalence in the “Young” group compared to controls was 6.2% vs 0%, while in the “Geriatric” was “68.2% vs 3.6%. Using “Young” as a reference, in multivariate analyses, predictors for MM were as follows: HIV serostatus (OR=47.75, IQR 14.78-154.25, p<0.01) and “Geriatric” vs “Young” (OR=30.32, IQR 5.89-155.98, p<0.01). Conclusion: These data suggest that age at acquisition of HIV should be considered as a risk factor for NICM and MM.
G. Guaraldi ; A. Malagoli ; J. Milic ; I. Pintassilgo ; E. Rossi ; N. Riva ; I. Franconi ; A. Santoro ; P. Sorin ; A. Streinu-Cercel ; M. De Rosa ; C. Mussini (2019): Age OF HIV acquisition affects the risk of multi-morbidity after 25 years of infection exposure. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2019.6