FRAILTY IN POSTMENOPAUSAL AFRICAN AMERICAN AND HISPANIC HIV-INFECTED WOMEN
P. Young, J. Shah, C. Zhang, D.C. Ferris, I. Colon, M. Bucovsky, M. Punyanitya, D.J. McMahon, E. Shane, M.T. Yin
J Frailty Aging 2016;5(4):242-246
Studies suggest frailty occurs earlier in HIV-infected individuals, but data in postmenopausal HIV-infected women are lacking. We assessed the prevalence of frailty and association with anthropometric measures in HIV-infected and uninfected postmenopausal women. Fried’s frailty phenotype was measured in HIV-infected and uninfected Hispanic and African American postmenopausal women participating in a study of bone metabolism; fat and lean mass were measured by whole body dual energy x-ray absorptiometry (DXA). Multivariable logistic regression evaluated frailty risk factors. The study was conducted at Columbia University Medical Center between 2002 and 2007. The participants were 61 HIV-infected and 27 uninfected Hispanic and African American postmenopausal women. The study compared prevalence and predictors of frailty in HIV-infected and uninfected postmenopausal women. Prevalence of frailty tended to be higher among HIV-infected than uninfected controls (11.5% vs 0% p=0.07). Surprisingly, among HIV-infected women, total body fat, not lean mass, was associated with frailty in multivariate analysis. Higher prevalence of frailty in African American and Hispanic HIV-infected postmenopausal women (11.5%) was similar to the 11% prevalence reported in minority women who were 10 years older in the general population. Our data suggest that frailty occurs earlier in HIV-infected postmenopausal women, but larger longitudinal studies are necessary to confirm whether musculoskeletal aging is accelerated by HIV infection.
P. Young ; J. Shah ; C. Zhang ; D.C. Ferris ; I. Colon ; M. Bucovsky ; M. Punyanitya ; D.J. McMahon ; E. Shane ; M.T. Yin (2016): Frailty in postmenopausal African American and Hispanic HIV-infected women. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2016.104