25-OH-VITAMIN D IS NOT ASSOCIATED WITH COGNITIVE PERFORMANCE AMONG MEXICAN COMMUNITY-DWELLING OLDER PERSONS
A.P. Navarrete-Reyes, I. García-Muñoz , J.M.A. García-Lara, N.M. Torres-Carrillo , H. Amieva , J.A. Avila-Funes
J Frailty Aging 2015;4(2):74-79
Background: Low cognitive performance has been associated with a wide array of adverse health-related outcomes in elderly populations. Recently, the effect of vitamin D on cognition has been studied; however, its benefits are still controversial. Moreover, most studies have been carried out on North-American and European populations where vitamin D deficiency could represent a greater public-health issue when compared to Latin American ones. Objective: To investigate the association between 25-OH-vitamin D and cognitive performance in Mexican community-dwelling elderly. Design, Setting and Participants: Cross-sectional study sample of 331 community-dwelling elderly aged 70 and older, participating in the Mexican Study of Nutritional and Psychosocial Markers of Frailty. Measurements: Serum 25-OH-vitamin D, cognitive performance as per the Mini-Mental State Examination (MMSE) and the IST (Isaacs Set Test), as well as several elements from the comprehensive geriatric assessment. Results: Mean age of participants was 79.3 years (SD 5.9), 54.1% were women. The mean serum 25-OH-vitamin D level was 59.0 (SD 23.3) nmol/L while mean MMSE score was 22.3 (SD 3.4) and mean IST score was 37.1 (SD 9.1). Although 25-OH-vitamin D levels were lower across all the definitions of low cognitive perfomance, the difference between groups was not statistically significant in any of them. Conclusion: No association between 25-OH-vitamin D level and cognitive performance was found in this population of Mexican community-dwelling elderly. Further investigation is required in order to clarify its existence and if so, to delineate its characteristics.
A.P. NAVARRETE-REYES ; I. GARCÍA-MUÑOZ ; J.M.A. GARCÍA-LARA ; N.M. TORRES-CARRILLO ; H. AMIEVA ; J.A. AVILA-FUNES (2015): 25-OH-VITAMIN D IS NOT ASSOCIATED WITH COGNITIVE PERFORMANCE AMONG MEXICAN COMMUNITY-DWELLING OLDER PERSONS. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2015.44