KLOTHO, FGF21 AND FGF23: NOVEL PATHWAYS TO MUSCULOSKELETAL HEALTH?
B. Bartali, R.D. Semba, A.B. Araujo
J Frailty Aging 2013;2(4):179-183
Bone mineral density, muscle mass and physical function reach their peak between the second and fourth decade of life and then decline steadily with aging. The crucial question is: what factors contribute to or modulate this decline? The aim of this mini-review is to propose a theoretical framework for the potential role of emerging biomarkers such as klotho, fibroblast growth factors (FGF)21 and FGF23 on musculoskeletal health, with a particular focus on decline in muscle mass and function, and calls for future research to examine this proposed link. The identification of new physiological mechanisms underlying these declines may open a potentially important avenue for the development of novel intervention strategies aimed at preventing or reducing their potentially detrimental consequences.
B. Bartali ; R.D. Semba ; A.B. Araujo (2013): Klotho, FGF21 and FGF23: Novel Pathways to Musculoskeletal Health?. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2013.26