journal articles
ASSOCIATIONS BETWEEN INTRINSIC CAPACITY, PLASMA P-TAU181 AND COGNITIVE FUNCTION OVER A 5-YEAR FOLLOW-UP AMONG COMMUNITY-DWELLING OLDER ADULTS: A SECONDARY ANALYSIS OF THE MAPT STUDY
Kelly Virecoulon Giudici, Philipe de Souto Barreto, Christelle Cantet, Henrik Zetterberg, Kaj Blennow, Bruno Vellas, or the MAPT/DSA group
BACKGROUND: Intrinsic capacity (IC) is a recent key concept proposed by the World Health Organization (WHO) based on aspects of functional ability (both physical and mental) rather than the presence or absence of diseases, with a potential to predict several health outcomes.
OBJECTIVE: To explore associations between IC and cognitive function (prospectively), and between IC and plasma p-tau181 (cross-sectionally and prospectively) among community-dwelling older adults.
METHODS: Observational study with 491 subjects ≥70 years (67.4 % female, mean 75.3 years, SD=4.4), participants from the Multidomain Alzheimer Preventive Trial (MAPT). IC domains (locomotion, cognition, psychological, vitality) were combined into a 0–100 score. Alternative classification was based on the number of domains’ abnormalities. Plasma p-tau181 was measured at baseline and 36 months of follow-up. A composite cognitive score (CCS) based on four tests was determined at baseline, 6, 12, 24, 36, 48 and 60 months.
RESULTS: Inverse cross-sectional associations were observed between baseline IC score and p-tau181 (unadjusted model: β=-0.08, 95 %CI -0.13 to -0.03; p = 0.0025). A significant mean difference in p-tau181 3-year changes was observed between participants with low and normal IC (based on IC score) (adjusted model: 1.71, 95 %CI 0.01 to 3.40; p = 0.0483). Prospective 5-year associations between IC and CCS were only observed in unadjusted analysis according to the alternative IC classification (-0.21, 95 %CI -0.38 to -0.04; p = 0.0156).
CONCLUSION: IC was associated with plasma p-tau181 and cognitive function, but findings varied according to the method of IC classification. Further research may help settle the role of IC as a predictor of neurodegenerative diseases such as AD. In this regard, multidomain interventions have potential to protect IC over the aging process and prevent cognitive impairment, and should also be encouraged.
CITATION:
Kelly Virecoulon Giudici ; Philipe de Souto Barreto ; Christelle Cantet ; Henrik Zetterberg ; Kaj Blennow ; Bruno Vellas ; for the MAPT/DSA group (2025): Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100064