06/2025 journal articles
IMPACTS OF SARCOPENIA AND RESISTANCE EXERCISE TRAINING ON MITOCHONDRIAL QUALITY CONTROL PROTEINS
Catherine B. Springer-Sapp, Olayinka O. Ogbara, Odessa Addison, Sarah Kuzmiak-Glancy, Steven J. Prior
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: The progression of sarcopenia with aging may be related to mitochondrial dysfunction due in part to altered mitochondrial dynamics (fusion, fission, mitophagy, and biogenesis). Previous work has identified altered expression of proteins associated with these processes in with aging, but whether further changes occur in sarcopenia remains unclear.
OBJECTIVES: The purpose of this study was to assess protein expression of markers of mitochondrial fusion (Mfn2, Opa1), fission (Drp1, Fis1), mitophagy (Parkin), biogenesis (PGC-1α), and content (Complex IV: CIV) in sarcopenic and non-sarcopenic older adults. We also determined whether resistance training affected skeletal muscle mitochondrial content and expression of mitochondrial quality control proteins in sarcopenic older adults.
DESIGN: Longitudinal exercise training study, with cross-sectional baseline comparison.
SETTINGS AND PARTICIPANTS: Ten older adults with mild-moderate sarcopenia, plus ten non-sarcopenic, matched older adults from Maryland, USA.
INTERVENTION: Twelve-week resistance training.
MEASUREMENTS: Strength, sarcopenic index (ALM/BMI: appendicular lean mass divided by body mass index), body composition, and mitochondrial morphology and protein expression in vastus lateralis muscle.
RESULTS: No differences in protein expression were observed between sarcopenic and non-sarcopenic participants at baseline; however, ALM/BMI was inversely related to CIV expression (r = -0.55, P = 0.013) across all subjects. Similarly, lean body mass and ALM correlated inversely with expression of the fusion protein Opa1-S (r = -0.55 - -0.51, P ≤ 0.022). Resistance training increased strength in sarcopenic older adults by 13 % (P = 0.02), but this group’s expression of mitochondrial quality control proteins was mostly unaltered.
CONCLUSIONS: The presence of sarcopenia identified by ALM/BMI was not associated with changes in protein expression that are consistent with impaired mitochondrial dynamics beyond those changes that might occur with aging alone. While short-term resistance training increased strength in older adults with sarcopenia, this was not accompanied by changes in protein expression, with the possible exception of fusion protein Mfn2.
CITATION:
Catherine B. Springer-Sapp ; Olayinka O. Ogbara ; Odessa Addison ; Sarah Kuzmiak-Glancy ; Steven J. Prior (2025): Impacts of sarcopenia and resistance exercise training on mitochondrial quality control proteins. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100090
WALKING THROUGH AGING: A REVIEW OF GAIT LABORATORY-BASED ASSESSMENTS AND GERIATRIC SYNDROMES
Catherine van\'t Hoff, Anthony Bull, Michael Fertleman
J Frailty Aging 2025;14(6)
Show summaryHide summaryGait is a complex, multifaceted process involving multiple organ systems. Both gait and transfer activities are key requirements for independent living. As individuals age, gait undergoes characteristic changes, including reduced walking speed, altered stride length, and increased variability. These changes are closely linked to the frailty syndromes of immobility, instability, cognitive impairment, incontinence, and iatrogenic harm.
Alterations in gait and transfer activities can serve as early predictors of falls, increased dependency, cognitive decline, and depression. Urinary incontinence and nocturia are associated with reduced mobility, a higher risk of falls, and fractures. Notably, the urge to void itself can influence gait patterns. Medications, particularly anticholinergics and polypharmacy, further contribute to gait disturbances, compounding falls risk.
Given its strong association with cognitive and functional decline, gait analysis is a crucial component of comprehensive geriatric evaluation. Recognising and addressing gait abnormalities can enhance patient outcomes by mitigating the broader impact on geriatric frailty syndromes.
CITATION:
Catherine van't Hoff ; Anthony Bull ; Michael Fertleman (2025): Walking through aging: A review of gait laboratory-based assessments and geriatric syndromes. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100103
SATISFACTION WITH COMMUNITY WALKING PROGRAM (WALK ON!): OLDER ADULTS AND PROGRAM LEADERS’ PERSPECTIVE
Rahma Ajja, Elizabeth Chmelo Kemp, Tami Guerrier, Justin B. Moore, Jaime M. Hughes, Mark A. Hirsch, Barbara Nicklas
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: Community-based programs play a critical role in providing frail older adults with a safe environment to engage in physical activity. Satisfaction is a key indicator of such programs’ acceptability while also playing a significant role in older adults’ long-term participation in physical activity. Moreover, program leaders’ satisfaction with training and confidence in program delivery are essential for ensuring the effectiveness and sustainability of community-based programs. The Walk On! program is a 12-week structured community-based program consisting of 24 sessions each lasting 60 min, designed for older adults with mobility challenges. Evaluating older adults’ satisfaction with the Walk On program and program leaders’ satisfaction with the training is crucial for informing strategies to facilitate broader dissemination and sustained implementation.
OBJECTIVES: To evaluate older adults’ (1) satisfaction with the Walk On! program, (2) perceived benefits on walking ability and overall well-being, and (3) program leaders’ satisfaction with the Walk On! training.
DESIGN: Pilot implementation trial.
SETTING: Four community organization sites located in North Carolina, USA.
PARTICIPANTS: 42 older adult participants (mean age 79 years old; 87% female) and 9 all-female program leaders.
MEASUREMENTS: Older adult participants’ survey was completed at the end of the 12-week program cycle. Program leaders’ survey was completed at the end of the training workshops.
RESULTS: Older adult participants reported high satisfaction with the Walk On! program (n = 42, 100%), and perceived improvements across multiple domains: including strength and endurance, social support and enjoyment, walking confidence, self-efficacy and goal setting, and balance after program participation. All program leaders (n = 9) rated the training as either excellent (67%) or good (33%) and reported that the training was relevant and provided adequate preparation to lead the Walk On! program.
CONCLUSION: The Walk On! program was acceptable and perceived as impactful among older adult participants, and program leaders were highly satisfied with the Walk On! training. Together, these positive findings support the scaling and expansion of Walk On! into additional community settings.
CITATION:
Rahma Ajja ; Elizabeth Chmelo Kemp ; Tami Guerrier ; Justin B. Moore ; Jaime M. Hughes ; Mark A. Hirsch ; Barbara Nicklas (2025): Satisfaction with community walking program (Walk On!): Older adults and program leaders’ perspective. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100112
“BALANCE T” DEVICE IMPROVES BALANCE CONFIDENCE AND PERFORMANCE IN REPEATED MEASURES STUDY
Courtney Walker, June Nicholas, Crystal Szczesny, Jeremy Walston, Yuri Agrawal, Michael C Schubert
J Frailty Aging 2025;14(6)
Show summaryHide summaryPURPOSE: The purpose of this research is to determine if balance can be improved in older adults from exercising at home using a novel piece of exercise equipment called the “Balance T”.
METHOD: Fifty older adults (77.9 ± 6.7 years old) participated in a four-week home exercise, open-label clinical pilot study investigating ability to improve balance using the Balance T device. Pre- and post-intervention assessments included the Activities-specific Balance Confidence (ABC) Scale, Short Physical Performance Battery (SPPB), Timed Up and Go (TUG), Clinical Test of the Sensory Interaction on Balance (CTSIB), Balance T Change Score (BTCS), and a user-opinion survey. Statistical analyses comprised parametric and non-parametric tests for pre-post exercise comparisons as well as evaluated balance differences across frailty status using established frailty-defining criteria.
RESULTS: Frail participants at-risk for falls exhibited greater improvement in balance confidence compared to robust participants, with a mean change of 5.28 ± 12.9 (p < 0.001). In addition, each performance variable of balance showed clinically significant and meaningful changes after completing the Balance T exercise program. Participants reported the Balance T device as easy and safe to use with benefits gained at improving their balance.
CONCLUSION: The Balance T device proved feasible for home use, showing preliminary evidence of improved balance performance and confidence, particularly among frail adults.
CITATION:
Courtney Walker ; June Nicholas ; Crystal Szczesny ; Jeremy Walston ; Yuri Agrawal ; Michael C Schubert (2025): “Balance T” device improves balance confidence and performance in repeated measures study. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100113
THE INTERRELATIONSHIP OF FRAILTY, MULTIMORBIDITY AND DISABILITY IN PARKINSON’S DISEASE: PRIME-UK CROSS-SECTIONAL STUDY
Emma Tenison, Yoav Ben-Shlomo, Anahita Nodehi, Emily J Henderson
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: The prevalence of Parkinson’s disease rises with age and so patients may also be living with multimorbidity, two or more long-term conditions, and frailty, a loss of physiological reserve. However, these individuals are typically under-represented in clinical research. The aim was to describe the prevalence and interrelationship of frailty, multimorbidity, disability, sarcopenia and polypharmacy in a representative sample of people with parkinsonism recruited to the PRIME-UK cross-sectional study.
METHODS: In this single-centre cross-sectional study of people with parkinsonism, we supported the inclusion of typically under-represented groups including those with impaired capacity to consent to the research. Participants, or their representative, completed questionnaires including self-reported comorbidities, medications, a sarcopenia screening tool and measures of frailty and disability. Venn diagrams were used to show the overlap between these domains and a hierarchical cluster analysis was performed to explore clustering.
RESULTS: Only 78 (16.8 %) were categorised as neither frail nor multimorbid nor disabled. Almost all patients living with frailty were additionally living with disability and/or multimorbidity. It was uncommon to have multimorbidity and frailty without disability. Only 6 (1.3 %) had frailty without probable sarcopenia. Individuals clustered into three groups based on co-occurrence of some or all of these five domains.
CONCLUSIONS: Amongst a representative sample of people with parkinsonism, there was a high frequency and co-occurrence of pre-frailty/frailty, sarcopenia, multimorbidity, polypharmacy and disability. This has implications for the structuring of health services for people with parkinsonism. There may also be opportunities to intervene to stop or slow the trajectory towards disability.
CITATION:
Emma Tenison ; Yoav Ben-Shlomo ; Anahita Nodehi ; Emily J Henderson (2025): The interrelationship of frailty, multimorbidity and disability in Parkinson’s disease: PRIME-UK cross-sectional study. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100073
THE INFLUENCE OF ETHNICITY ON FRAILTY IN A UNITED KINGDOM (UK) POPULATION
AH Heald, W Lu, R Williams, K Mccay, A Clegg, C Todd, A Maharani, MJ Cook, TW O’Neill
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: Frailty is an important and increasing clinical and public health problem. Within the United Kingdom (UK). Most data relating to the occurrence of frailty is derived from Caucasian groups. This study aimed to determine the influence of ethnicity on the occurrence of frailty in a large UK urban conurbation. We also looked at frailty-related risk of severe illness related to COVID-19 infection.
METHODS: Using data from the Greater Manchester Health Record (GMCR), we analysed primary care electronic medical records of 534,367 men and women aged 60 years and over who were alive on 1st January 2020. We assessed frailty using an electronic frailty index (eFI) and categorised subjects as fit, mild, moderate, and severe frailty. We used logistic regressions to examine the association between moderate and severe frailty (eFI ≥ 0.25) and ethnicity adjusted with age, sex and area deprivation (as measured using Townsend Index). We also looked among those with a first positive COVID test, the influence of frailty on subsequent admission to the hospital within 28 days.
RESULTS: The majority of subjects were White (84 %), with 4.7 % describing themselves as Asian or Asian British, and 1.3 % Black or Black British. The unadjusted prevalence of moderate to severe frailty (eFI ≥ 0.25) was 22.1 %. Compared to the prevalence of frailty in Whites (22.5 %), the prevalence was higher in those of Asian or Asian British ethnicity (28.1 %) and lower in those of Black/Black British descent (18.7 %). After adjustment for age, gender, and deprivation, the risk of frailty remained higher in Asians (Odds Ratio = 1.61; 95 % Confidence Intervals = 1.56–1.66) and lower in Black British (OR = 0.73; 95 % CI 0.68–0.78) compared to White British. Among those with a positive COVID-19 test, those with frailty were more likely to require admission to the hospital within 28 days (OR = 1.61; 95 % CI = 1.53, 1.69).
CONCLUSIONS: There is variation in the occurrence of frailty across Greater Manchester across ethnic groups, with higher frequency among those of Asian or Asian British descent and lower frequency among those of Black or Black British descent. This study has added to our understanding of the way that frailty prevalence maps across communities, in this case in a large European conurbation. Further research is required to understand the causes of ethnic variation in frailty and whether ethnicity influences frailty outcomes.
CITATION:
AH Heald ; W Lu ; R Williams ; K Mccay ; A Clegg ; C Todd ; A Maharani ; MJ Cook ; TW O’Neill (2025): The influence of ethnicity on frailty in a United Kingdom (UK) population. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100089
FRAILTY ASSESSMENT UTILIZATION AROUND THE GLOBE–A SYSTEMATIC REVIEW
Samantha Gaston, Elle Billman, Lichy Han, David Drover
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: Recent expert guidelines recommend that frailty assessments (FAs) encompass physical, functional, cognitive, social, and mental health domains. This systematic review examines FAs administered globally between 2015 to 2022 in geriatric participants (65 years and older) to characterize the parameters used to assess frailty.
METHODS: Following PRISMA guidelines, we screened 3,859 articles and included 202 in the final analysis. FA parameters were coded into 45 health-related categories defined by the authors to evaluate the domains most frequently used.
RESULTS: Across 39 countries, 291 FAs were identified, with an average number of 17.36 parameters per instrument. Of the 4,995 total parameters analyzed, 22.32 % assessed functional health or physical performance. Cognitive, mental, and social health were assessed by only 6.09 %, 6.35 %, and 5.01 % of parameters, respectively.
CONCLUSIONS: FAs overwhelmingly measure functional and physical health parameters with limited attention to cognitive, mental, and social domains. This imbalance suggests that instruments may fall short of capturing the multidimensional nature of frailty as recommended by recent guidelines. By cataloging current FAs, their components, and the degree to which they reflect comprehensive frailty definitions, this review highlights the need for further research and refinement of FAs to ensure accurate, holistic assessment across diverse clinical settings.
CITATION:
Samantha Gaston ; Elle Billman ; Lichy Han ; David Drover (2025): Frailty assessment utilization around the globe–a systematic review. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100088
A TWO-STAGE ANALYSIS OF SOCIAL MEDIA USE PATTERNS, PSYCHOSOCIAL WELL-BEING, AND FRAILTY IN AN AGING JAPAN
Yuki Nakada, Yuna Seo
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: In Japan's super-aged society, frailty prevention is a critical public health issue. While social media use is increasing among older adults, its impact on well-being is complex and not fully understood beyond a simple active-passive dichotomy. This study aims to explore the relationship between specific social media usage patterns, users' psychosocial backgrounds, and frailty risk.
METHODS: We conducted a cross-sectional online survey of 950 community-dwelling older adults in Japan. Frailty was assessed using the Kihon Checklist. A two-stage analysis was performed: 1) K-means cluster analysis was used to classify participants based on eight SOCIAL MEDIA use behavior variables, followed by a Kruskal-Wallis test to compare psychosocial characteristics across clusters; 2) Ordinal logistic regression analysis was used to identify specific behaviors associated with frailty after adjusting for covariates.
RESULTS: Three distinct user clusters were identified: “Balanced, reality-oriented communicators” (n = 333), “Low-engagement, passive users” (n = 419), and “Active, multi-purpose users” (n = 198). The “Low-engagement” group reported the highest levels of loneliness and unhappiness, despite high real-world social participation. Regression analysis revealed that the specific behavior of “using social media to keep a record of my own activities” (self-documentation) was independently associated with an increased risk of frailty (β = 0.105, p < .05). Conversely, high exercise self-efficacy (p < .001), sleep satisfaction (p < .01), and satisfaction with face-to-face communication (p < .001) were protective factors.
CONCLUSION: Social media usage patterns reflect underlying psychosocial states, but are not direct predictors of frailty. The motivation-driven behavior of self-documentation, rather than general activity, is a risk factor. These findings suggest that interventions should focus on the quality and function of social media use, promoting digital literacy that enhances well-being in older adults.
CITATION:
Yuki Nakada ; Yuna Seo (2025): A two-stage analysis of social media use patterns, psychosocial well-being, and frailty in an aging Japan. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100091
LIFE-COURSE SOCIO-ECONOMIC FACTORS ASSOCIATED WITH FRAILTY IN LATER LIFE
Mathilde Glud Christensen, Katja Kemp Jacobsen, Charlotte Juul Nilsson, Randi Jepsen, Lau Caspar Thygesen, Charlotte Suetta, Ellen Astrid Holm
J Frailty Aging 2025;14(6)
Show summaryHide summaryPURPOSE: Frailty increases with age and is associated with negative health outcomes as falls, hospitalization, and mortality. Socio-economic situation (SES) in childhood and adulthood are associated with frailty. It is unclear how the interaction of childhood hardship and adulthood SES effects frailty.
METHODS: A register-based study using data from national registers and from the Lolland-Falster Health Study, involving individuals aged 50 and above. Frailty status was assessed using a modified version of Fried’s phenotype. Logistic regression models with multiple adjustments were used to analyze the odds of frailty. Causal interactions between economic hardship in adulthood, perception of childhood, self-reported stressful events in childhood, and self-reported educational level were assessed by estimating the relative excess risk due to interaction (RERI).
RESULTS: The study included 10,163 individuals. The percentage of individuals fulfilling 2–5 frailty criteria varied between 17 % in the 50–65 age group and 44.9 % in the 85+ age group. Women had a higher proportion of fulfilling 2–5 frailty criteria (21.5 %) compared to men (17.2 %). Socio-economic factors associated with frailty status included perception of childhood, stressful childhood events, educational attainment, and economic hardship in adulthood. A significant causal additive effect on the percentage of individuals fulfilling 2–5 frailty criteria was demonstrated for two composite outcomes: perception of childhood + educational attainment and stressful events in childhood + economic hardship in adulthood.
CONCLUSION: The study showed that joint exposure to adverse socio-economic factors in childhood and adulthood, potentiated the odds of frailty in older adults. Our findings corroborate the theory of cumulative dis/advantage.
CITATION:
Mathilde Glud Christensen ; Katja Kemp Jacobsen ; Charlotte Juul Nilsson ; Randi Jepsen ; Lau Caspar Thygesen ; Charlotte Suetta ; Ellen Astrid Holm (2025): Life-course socio-economic factors associated with frailty in later life. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100107
FRAIL2FIT STUDY: IT WAS FEASIBLE AND ACCEPTABLE FOR VOLUNTEERS TO DELIVER A REMOTE HEALTH INTERVENTION TO OLDER ADULTS WITH FRAILTY
SJ Meredith, L Holt, J Varkonyi-Sepp, A Bates, KA Mackintosh, MA McNarry, S Jack, J Murphy, MPW Grocott, SER Lim
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: Physical activity (PA) and good nutrition are key to maintaining independence and reversing frailty among older adults.
OBJECTIVE: To evaluate the feasibility and acceptability of training volunteers to deliver a remote multimodal intervention to older people with frailty after hospital discharge.
DESIGN: Quasi-experimental mixed-methods feasibility study.
SETTING, AND PARTICIPANTS: Twenty-seven older adults (mean age 80 years, 15 female) with frailty (Clinical Frailty Status ≥5) were enrolled from a National Health Service South England hospital, UK.
INTERVENTION: Volunteers were trained to deliver a 3-month intervention, comprising exercise, behaviour change, and nutrition guidance in a group, or one-to-one, using telephone or online platforms.
MEASUREMENTS: Feasibility was assessed by determining the number of volunteers recruited, trained, and retained; participant recruitment; and intervention adherence. Interviews were conducted with 16 older adults, 1 carer, and 5 volunteers to explore intervention acceptability, and were analysed using reflexive thematic analysis. Secondary health outcomes, such as physical activity and appetite, were compared at baseline, post-intervention, and follow-up (3-months).
RESULTS: The intervention was safe and acceptable to volunteers, and older adults with frailty. Five volunteers (mean age 16 years, 3 female) completed training, and 60 % (n = 3) were retained. Seventeen participants completed the intervention (8 online; 9 telephone). Participants attended 75 % (IQR 38–92) online sessions, and 80 % (IQR 68.5–94.5) telephone support. Volunteers provided emotional support to older people with frailty and encouraged health behaviour change. Older people learnt from each other’s shared experiences in the online group, and telephone calls provided them with reassurance and monitoring. Key components to success were volunteers received comprehensive training and support from a health practitioner, while key barriers were that participants lacked social support and experienced exercise discomfort.
CONCLUSION: With appropriate training and support, volunteers can safely deliver a remote multimodal intervention for older adults with frailty following discharge from hospital.
CITATION:
SJ Meredith ; L Holt ; J Varkonyi-Sepp ; A Bates ; KA Mackintosh ; MA McNarry ; S Jack ; J Murphy ; MPW Grocott ; SER Lim (2025): Frail2Fit study: it was feasible and acceptable for volunteers to deliver a remote health intervention to older adults with frailty. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100092
EXPLORATORY FUNCTIONAL AND QUALITY OF LIFE OUTCOMES WITH DAILY CONSUMPTION OF THE KETONE ESTER BIS-OCTANOYL (R)-1,3-BUTANEDIOL IN HEALTHY OLDER ADULTS: A RANDOMIZED, PARALLEL ARM, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
Brianna J Stubbs, Elizabeth B Stephens, Tyler Mansfield, Chatura Senadheera, Stephanie Roa Diaz, Sawyer Peralta, Laura Alexander, Wendie Silverman-Martin, Jamie Kurtzig, B? Ashen Fernando, Thelma Y Garcia, Michi Yukawa, Jennifer Morris, James T Yurkovich, Anne B. Newman, James B Johnson, Peggy M. Cawthon, John C Newman
J Frailty Aging 2025;14(6)
Show summaryHide summaryBACKGROUND: Ketone bodies are metabolites produced during fasting or on a ketogenic diet that have pleiotropic effects on the inflammatory and metabolic aging pathways underpinning frailty in vivo models. Ketone esters (KEs) are compounds that induce hyperketonemia without dietary changes and that may impact physical and cognitive function in young adults. The functional effects of KEs have not been studied in older adults.
OBJECTIVES: Our long-term goal is to examine if KEs modulate aging biology mechanisms and clinical outcomes relevant to frailty in older adults. Here, we report the exploratory functional and quality-of-life outcome measures collected during a 12-week safety and tolerability study of KE (NCT05585762).
DESIGN: Randomized, placebo-controlled, double-blinded, parallel-group, pilot trial of 12-weeks of daily KE ingestion.
SETTING: The Clinical Research Unit at the Buck Institute for Research on Aging, California.
PARTICIPANTS: Community-dwelling older adults (≥65 years), independent in activities of daily living, with no unstable acute medical conditions (n = 30).
INTERVENTION: Participants were randomly allocated (1:1) to consume 25 g daily of either KE (bis-octanoyl (R)-1,3-butanediol) or a taste, appearance, and calorie-matched placebo (PLA) containing canola oil.
MEASUREMENTS: Longitudinal change in physical function, cognitive function and quality of life were assessed as exploratory outcomes in n = 23 completers (n = 11 PLA, n = 12 KE). A composite functional outcome intended for interventional frailty trials was derived and calculated. Heart rate and activity was measured throughout the study using digital wearables.
RESULTS: There were no statistically significant longitudinal differences between groups in exploratory functional, activity-based or quality of life outcomes.
CONCLUSION: Daily ingestion of 25 g of KE did not affect exploratory functional or quality-of-life end points in this pilot cohort of healthy older adults. Future work will address these endpoints as primary and secondary outcomes in a larger trial of pre-frail older adults.
CITATION:
Brianna J Stubbs ; Elizabeth B Stephens ; Tyler Mansfield ; Chatura Senadheera ; Stephanie Roa Diaz ; Sawyer Peralta ; Laura Alexander ; Wendie Silverman-Martin ; Jamie Kurtzig ; B․ Ashen Fernando ; Thelma Y Garcia ; Michi Yukawa ; Jennifer Morris ; James T Yurkovich ; Anne B. Newman ; James B Johnson ; Peggy M. Cawthon ; John C Newman (2025): Exploratory functional and quality of life outcomes with daily consumption of the ketone ester bis-octanoyl (R)-1,3-butanediol in healthy older adults: a randomized, parallel arm, double-blind, placebo-controlled study. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100106
LETTER TO THE EDITOR : THE INTERSECTION OF MITOCHONDRIAL DYNAMICS AND SARCOPENIC PHENOTYPING: A CALL FOR MECHANISTIC DETAIL
Parth Aphale, Himanshu Shekhar, Shashank Dokania
J Frailty Aging 2025;14(6)
Show summaryHide summary
CITATION:
Parth Aphale ; Himanshu Shekhar ; Shashank Dokania (2025): Letter to the Editor: The intersection of mitochondrial dynamics and sarcopenic phenotyping: A call for mechanistic detail. The Journal of Frailty and Aging (JFA). https://doi.org/10.1016/j.tjfa.2025.100116