CIRCULATING CD34-POSITIVE CELLS ARE ASSOCIATED WITH HANDGRIP STRENGTH IN JAPANESE OLDER MEN: THE NAGASAKI ISLANDS STUDY
H. Yamanashi, Y. Shimizu, J. Koyamatsu, M. Nagayoshi, K. Kadota, M. Tamai, T. Maeda
J Frailty Aging 2017;6(1):6-11
Background: Handgrip strength is a simple measurement of overall muscular strength and is used to detect sarcopenia. It also predicts adverse events in later life. Many mechanisms of sarcopenia development have been reported. A hypertensive status impairs endothelial dysfunction, which might deteriorate skeletal muscle if vascular angiogenesis is not maintained. Objectives: This study investigated muscle strength and circulating CD34-positive cells as a marker of vascular angiogenesis. Design: Cross-sectional study. Participants: 262 male Japanese community dwellers aged 60 to 69 years. Measurements: The participants’ handgrip strength, medical history, and blood samples were taken. We stratified the participants by hypertensive status to investigate the association between handgrip strength and circulating CD34-positive cells according to hypertensive status. Pearson correlation and linear regression analyses were used. Results: In the Pearson correlation analysis, handgrip strength and the logarithm of circulating CD34-positive cells were significantly associated in hypertensive participants (r=0.22, p=0.021), but not in non-hypertensive participants (r=−0.01, p=0.943). This relationship was only significant in hypertensive participants (ß=1.94, p=0.021) in the simple linear regression analysis, and it remained significant after adjusting for classic cardiovascular risk factors (ß=1.92, p=0.020). The relationship was not significant in non-hypertensive participants (ß=−0.09, p=0.903). Conclusions: We found a positive association between handgrip strength and circulating CD34-positive cells in hypertensive men. Vascular maintenance attributed by circulating CD34-positive cells is thought to be a background mechanism of this association after hypertension-induced vascular injury in skeletal muscle.
H. Yamanashi ; Y. Shimizu ; J. Koyamatsu ; M. Nagayoshi ; K. Kadota ; M. Tamai ; T. Maeda (2016): Circulating CD34-positive cells are associated with handgrip strength in Japanese older men: the Nagasaki Islands study. The Journal of Frailty and Aging (JFA). http://dx.doi.org/10.14283/jfa.2016.107